Preoperative magnetic resonance imaging use and oncologic outcomes in premenopausal breast cancer patients

CHIP Contributors: Yuan Luo, PhD


Abstract

Breast magnetic resonance imaging (MRI) delineates disease extent sensitively in newly diagnosed breast cancer patients, but improved cancer outcomes are uncertain. Young women, for whom mammography is less sensitive, are expected to benefit from MRI-based resection. We identified 512 women aged ≤50 years, undergoing breast-conserving treatment (BCT: tumor-free resection margins and radiotherapy) during 2006–2013 through Northwestern Medicine database queries; 64.5% received preoperative MRI and 35.5% did not. Tumor and treatment parameters were similar between groups. We estimated the adjusted hazard ratios (aHR) for local and distant recurrences (LR and DR), using multivariable regression models, accounting for important therapeutic and prognostic parameters. LR rate with MRI use was 7.9 vs. 8.2% without MRI, aHR = 1.03 (95% CI 0.53–1.99). DR rate was 6.4 vs. 6.6%, aHR = 0.89 (95% CI 0.43–1.84). In 119 women aged ≤40, results were similar to LR aHR = 1.82 (95% CI 0.43–7.76) and DR aHR = 0.93 (95% CI 0.26–3.34). Sensitivity analyses showed similar results. The use of preoperative MRI in women aged ≤50 years should be reconsidered until there is proof of benefit.


Full Citation

Zeng, Z., Amin, A., Roy, A., Pulliam, N. E., Karavites, L. C., Espino, S., Helenowski, I., Li, X., Luo, Y., & Khan, S. A. (2020). Preoperative magnetic resonance imaging use and oncologic outcomes in premenopausal breast cancer patients. NPJ breast cancer, 6, 49. https://doi.org/10.1038/s41523-020-00192-7

« Back To Publications View Article

Note: Publications may be freely available or require a fee to access on the journal’s website.

Join Us

CHIP collaborators are part of the public, private and nonprofit sectors and have an interest in working toward a world where health outcomes are improved because data is used effectively.

Get in Touch

Join Our Mailing List

Don't Forget To Connect